It's amazing how the advancement of science can help in the diagnosis and treatment of several illnesses. A new type of test, for example, can detect the toxin that is hidden in cases of Alzheimer's, according to a study published by PNAS. See more about the blood test that can predict Alzheimer's before the disease appears.
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The objective of the exam is to accelerate the diagnosis of these cases. This test will be able to give answers to many patients, and in this way, it will be possible to seek the proper care to treat the disease before it advances.
At the University of Washington, researchers made this great discovery, being responsible for creating the blood test. The test was designed to capture the molecular precursor in the blood.
Apparently, when someone is a carrier of Alzheimer's, the test causes proteins to fold and clump together in the brain, forming beta-amyloid (Aβ) plaques.
If you don't know, Aβ plaques are formed in Alzheimer's cases, however their role in the patient's cognitive process is uncertain. Throughout history, these plaques have been considered an initial trigger for neuron loss and dysfunction.
However, studies say that Aβ plaques are present in only a third of patients who have the disease. Thus, they are found in the brain of people, but they do not always cause cognitive deficits.
Scientists are still discovering more details, however, suspicion led them to perform a test soluble oligomer binding compound, dubbed SOBA, which was tested in the blood plasma of 310 volunteers. Some showed mild cognitive impairment or Alzheimer's disease, while others remained in good health.
By measuring toxic Aβ oligomers in blood plasma, SOBA identified all 53 participants with Alzheimer's who later had the disease.
However, Alzheimer's is not the only disease that has toxic oligomers. Deficient proteins can also be associated with Parkinson's, type II diabetes and dementia with Lewy bodies.
Other tests that sought to measure Alzheimer's traits have already been carried out, but their success was variable. In 2018, a blood analysis was performed that identified the Aβ precursors.
However, they predicted disease onset just 30 days before cognitive impairment became apparent. SOBA can make similar predilections.