Research carried out by researchers at the Karolinska Institute, in Sweden, and published in the journal Brain, seems to have found a way to carry out an examination to verify the possibility of Alzheimer's up to ten years in advance.
Alzheimer's brings as characteristic symptoms aggressiveness and forgetfulness, arriving at a more advanced stage of the disease. Thus, finding out in advance the incidence of such a neurodegenerative process is very important.
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In the conception of health professionals and scientists, with information on the progress of the disease in advance, it is possible to develop and seek mechanisms to stop the process.
According to the researchers, the biomarkers found in the blood are able to indicate the occurrence of early pathological changes in a hereditary species of the disease.
Thus, it was possible to verify that changes in glial fibrillary acidic protein (GFAP) occur about 10 years before the onset of Alzheimer's disease symptoms.
To reach the final result of the study, it was necessary for the group of researchers to evaluate 164 samples of blood plasma, taken from 33 people with a mutation that makes them more vulnerable to Alzheimer's, and also 42 relatives who did not have such a predisposition genetics.
The collection was carried out between 1994 and 2018, and, according to the analyses, there are clear changes in several concentrations of blood proteins in those who carried the mutation, with a decade before the appearance of the first symptoms.
According to Caroline Graff, a professor at the Department of Neurobiology, Care Sciences and Society of the Karolinska Institute, who is also one of the authors of the research:
“They were followed by increased concentrations of P-tau181 (tau protein) and subsequently Nfl (light protein of neurofilament), which, we already know, are directly associated with the extent of neuronal damage in the brain of Alzheimer's.”
Thus, according to the analysis of the group of researchers, these results are very promising for new tests and approaches against Alzheimer's to be carried out in the future.
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