You can seem and if to feel better ifexercisingregularly, mto the you you knew what the physical activity also keepsyour bones and muscles strong?A weaknessmusculoskeletal, which affects people properties, causethe damageof the muscles and bones.Recently, researchers japanese discoveredone new medicine what he canto helpThedeal withillnesses caused by sedentary lifestyle, producingeffects similarto theof exercise.
A lackinexerciseshe can causeweaknessmuscular (sarcopenia) and us bones (osteoporosis).The exercisehelpThedissipatethis fragility,increasingthe power muscular and inhibiting The degradation of the bones, at the same time that it promotes the formation bone. At thehowever, Thephysiotherapy it can not be used in all the situations clinics.So, thepharmacotherapyéveryusefulat thetreatmentof these diseasesifOpatienthaveinsanity,illnesscerebrovascularoralreadyyou arebedridden.However, nonenumbinghe hasastarget both fabrics at the same time.
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Researchers from Tokyo Medical and Dental University (TMDU) used a new sorting system medicines in a study whathe was recentlypublishedin the magazine Bone Research, for identifycompounds what imitatechangesmuscular It is bonyinducedby the exercise.
So, the scientistsdiscoveredonederivativein aminoindazole, locamidazole (LAMZ). He is able to encouragethe growth of osteoblasts and cells bone-forming muscles. At the same time, it inhibits the formation of osteoblasts that destroy the bones.
THE LAMZ came in with successat bloodstream of mice when managed per via oral, without to present effects side effects apparent. “We were pleased to find that mice treated with LAMZ exhibitedbigger width in muscle fiber, biggerstrength maximum muscle, biggerrate of bone formation and smalleractivity of bone resorption”, said lead study author Takehito Ono.
The teamhe studiedyetmoreas O LAMZit works It is detected that he imitates the ways of signaling calcium and PGC-1α. When we practice physical activity, we activate these pathways during exercises, causing the expression of molecules to downstream involved in maintenancemuscular It is bony.
For investigate if O LAMZ can deal withriotslocomotives, the substance was usedin modelsanimals of sarcopenia and osteoporosis. "Aadministration oral and subcutaneous from thedamn it improved Omuscle It is Obonein mice with locomotor fragility”, stated Oauthor senior Tomoki Nakashima.
To the discoveries team's in searchsuggest that the LAMZ éoneoptionintreatmentpotentialfor cases of weaknessmuscularsimulatingexercises.
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