A person may need a transplant when their organs or tissues are functioning properly. insufficiently or have been damaged to the point of seriously compromising their health and/or quality of life.
Therefore, transplants are a treatment option when other medical interventions cannot resolve the underlying problem.
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When a vital organ, such as the heart, lungs, liver, kidneys, or pancreas, is not functioning properly due to chronic illness, serious injury, or congenital dysfunction, a transplant It may be the only option to prolong life.
However, this process is not always easy. In view of this, scientists continue to study alternatives to facilitate transplant surgeries.
In this sense, researchers at the University of California at San Francisco (UCSF), in the United States, are immersed in a cutting-edge project in the field of medicine.
This involves the development of an artificial kidney that, in perspective, could provide patients with freedom from the need for dialysis or organ transplants from human donors.
In a study released on August 29 in the journal Nature Communications, UCSF researchers detail that the device that they created relies on a bioreactor containing diverse kidney cells to mimic the body's crucial cellular functions human.
These functions include the ability to reabsorb water and solutes, release hormones, and regulate blood pressure. To protect these cells, they are encapsulated by silicon membranes in the artificial organ.
This is a measure that aims to prevent the patient's immune system from attacking the implant. Scientists aim to integrate this bioreactor with a device that helps in the filtration of blood of the receiver.
In this sense, the measurement follows a process similar to that used in dialysis. Furthermore, the co-author of the research and professor in the Department of Bioengineering and Therapeutic Sciences at UCSF, Shuvo Roy, states that the central idea is to safely reproduce the functions of the kidney.
The bioartificial kidney has the potential to not only improve the effectiveness of kidney disease treatment, but also make it considerably more bearable and comfortable for patients.
(Photo: Steve Babuljak/UCSF/publicity)
The first tests with the artificial kidney in pigs were successful, demonstrating more than 90% viability and cell functionality, along with normal or elevated gene expression and vitamin D activation after seven days.
However, the team still needs to conduct more tests before proceeding with experiments on humans, so in accordance with the requirements of the Food and Drug Administration (FDA), the federal health agency of the United States United.
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